How Effective Is Citalopram for Headaches?

Citalopram hydrobromide is a chemical, commonly known as citalopram hydrobromide tablets, trade name Xipumiao, has antidepressant effects.

Citalopram hydrobromide

Citalopram hydrobromide is a chemical, commonly known as citalopram hydrobromide tablets, trade name Xipumiao, has antidepressant effects.
Foreign name
Citalopram Hydrobromide
Dosage form
Non preparation: API
Drug type
chemical
Common name: Citalopram hydrobromide tablets
Product Name: Xipu Miao
Chinese alias Xipu Miao; 1- (3-Dimethylaminopropyl) -1- (4-fluorophenyl) -1,3-dihydroisobenzofuran-5-carbonitrile, hydrobromide; 1 -[3- (dimethylamino) propyl] -1- (4-fluorophenyl) -1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide; cetopram hydrobromide; Citalide hydrobromide; Citalopram hydrobromide
English name: Citalopram Hydrobromide Tablets
English alias 1- [3- (DIMETHYLAMINO) PROPYL] -1- (4-FLUOROPHENYL) -1,3-DIHYDRO-5-ISOBENZOFURANCARBONITRILE HYDROBROMIDE; CITALOPRAM HBR; (+/-)-CITALOPRAM HYDROBROMIDE; 5-isobenzofurancarbonitrile, 1- (3- (dimethylamino) propyl) -1- (4-fluorophenyl) -1,3; Citalopram Hydrobromide Tablets; 1- [3- (dimethylamino) propyl] -1- (4-fluorophenyl) -1,3-dihydroisobenzofuran- 5-carbonitrile monohydrobromide; 1- [3- (dimethylamino) propyl] -1- (4-fluorophenyl) -1,3-dihydro-2-benzofuran-5-carbonitrile hydrobromide (1: 1)
Chinese Pinyin: Qingxiusuan Xi Tai Pu Lan Pian
Chemical name: 1- (3-dimethylaminopropyl) -1- (4-fluorophenyl) -1,3-dihydroisobenzofuran-5-nitrile, hydrobromide
Citalopram hydrobromide is a very strong, selective
Citalopram hydrobromide is a strong, selective serotonin uptake inhibitor with antidepressant effects. Of particular interest is that this drug has no inhibitory effect on cholinergic muscarinic receptors, histamine receptors and alpha-adrenergic receptors. If these receptors are inhibited, there will be many side effects caused by antidepressants, such as dry mouth, sedation, orthostatic hypotension, etc. Citalopram hydrobromide is equally effective in patients with endogenous and non-endogenous depression, and its antidepressant effect is usually established after 2-4 weeks. Citalopram hydrobromide does not affect the cardiac conduction system and blood pressure, which is particularly important for elderly patients. In addition, citalopram hydrobromide does not affect the blood, liver and kidney systems. The rare side effects and mildest sedative properties of citalopram hydrobromide make it particularly suitable for long-term treatment. Moreover, citalopram hydrobromide neither causes weight gain nor strengthens the effects of alcohol.
The oral bioavailability of citalopram hydrobromide is approximately 80%. After taking the daily dose, the highest plasma level of citalopram hydrobromide can be reached within 2-4 hours, and the protein binding rate is less than 80%. Drugs and metabolites can cross the placental barrier, and their distribution in the fetus is similar to the mother's body. A small amount of the drug and its metabolites will enter the baby's body through breast milk during breastfeeding. The biological half-life is approximately 1 to 1.5 days and is excreted via urine and feces.
Depressive mental disorder (endogenous and non-endogenous depression).
Adults: Citalopram hydrobromide tablets are taken once daily.
The starting dose is 20 mg per day, which can be increased to 40 mg per day or the highest dose of 60 mg per day if clinically required.
For patients over 65 years of age, the dose is halved, ie 10-30 mg daily.
Antidepressant treatment belongs to
The side effects observed with citalopram hydrobromide are usually few, mild and transient. The most common adverse reactions were: nausea, increased sweating, decreased drooling, headaches, and reduced sleep time. It is usually noticeable in the first or second week of treatment, and generally disappears as the depression improves. Seizures have been observed in rare cases. Bradycardia can complicate treatment in patients with preexisting bradycardia.
Taboo and
Patients taking a monoamine oxidase inhibitor should not use citalopram hydrobromide at the same time, and citalopram hydrobromide should not be used until 14 days after the monoamine oxidase inhibitor is stopped. However, if using a reversible monoamine oxidase inhibitor with a short half-life, such as morphobexamide, citalopram hydrobromide can be used after one day of discontinuation.
Patients with liver dysfunction should start treatment at low doses and monitor carefully.
Because the anti-depressant effect of this product can precede the anti-depressant effect, the patient may still have the possibility of suicide before the obvious depression relief appears. If the patient enters the manic period, citalopram hydrobromide should be discontinued, and a psychosuppressive drug (such as benzclothiol (trade name: high resistance hormone)) should be given for appropriate treatment.
Impact on athletic behavior:
Citalopram hydrobromide has little or no effect on cognitive and psychomotor behavior.
Medication for pregnant and lactating women
The safety of citalopram hydrobromide in pregnant women has not been determined. Therefore, unless the benefits to the patient far outweigh the theoretical risks to the fetus or infant, they should not be taken during pregnancy and lactation.
Animal tests have not shown any evidence of possible teratogenicity. Moreover, citalopram hydrobromide does not affect reproductive or perinatal status. A small amount of citalopram hydrobromide can reach breastfeeding newborn animals through breast milk.
Medication for elderly patients
For patients over 65 years of age, the dose is halved, ie 10-30 mg daily.
Concomitant monoamine oxidase inhibitors can cause hypertension crisis.
Drug overdose

Citalopram hydrobromide symptoms

Take medicine up to 600mg: fatigue, weakness, drowsiness, dizziness, hand tremor, nausea. The maximum dose recorded was about 2000 mg. The patient was hospitalized in a state of stiffness and dyspnea, but there was no sign of heart poisoning, and the patient recovered quickly.

Citalopram hydrobromide treatment

Symptomatic treatment and supportive therapy. Stomach lavage as soon as possible after oral overdose, intubation to keep the airway open, oxygen inhalation during hypoxia, stability when convulsions occur, and 24-hour medical supervision is recommended.

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